
Sena Kathryn Jeter was born in Birmingham on June 28, 1942, to Flora Lee Sims Jeter, a music teacher, and Marvin Luther Jeter, a physician who died when she was 15 years old. She has two older brothers, both published writers.
As a child, Naslund was immersed in both reading and creating stories at Norwood Elementary School. She wrote a novel about pioneers at age nine and published her first short story in the Phillips High School newspaper, The Mirror. Enthusiastic about classical music, she played the cello in the Birmingham Youth and Alabama Pops orchestras. The University of Alabama offered her a music scholarship, but she felt she lacked sufficient talent to make a career of playing the cello. Therefore, she declined the offer and entered Birmingham-Southern College, where she studied English and creative writing and graduated with a bachelor's degree in 1964, after winning the B. B. Comer Medal in English. While at Birmingham-Southern, Jeter published short fiction, poetry, and literary criticism in the school's literary magazine, The Quad; wrote, directed, and produced a full-length historical tragedy, Boadicea: Queen of the Iceni; and attended the prestigious Bread Loaf Writer's Conference at Vermont's Middlebury College.

Naslund served as the director of the University of Louisville's creative writing program for 12 years. She also was a visiting professor of creative writing at Indiana University-Bloomington (1985-1986) and Vermont College (1982-2000) while continuing to teach at the University of Louisville. There, she taught undergraduate and graduate writing and literature courses and founded The Louisville Review, a literary journal, in 1976. In celebration of its twentieth year of publication, she established the Fleur-de-Lis Press, which publishes the first works of outstanding authors whose work has appeared in The Louisville Review.
Naslund first published professionally in 1972, when her story "Julius Geissler" appeared in The Iowa Review. Her first book, a collection of contemporary short stories titled Ice Skating at the North Pole, was published in 1989 by Roger Williams University's Ampersand Press. In 1993, she published two novels: The Animal Way to Love, a contemporary novel, and the first of her historical novels, Sherlock in Love, in which she imagines unexplored biographical elements of literature's most famous sleuth, Sherlock Holmes. Naslund continued the theme of exploring alternate readings of famous or literary characters in 1999's The Disobedience of Water: Stories and Novellas, which includes several pieces set in Alabama.

In her subsequent best seller, Four Spirits (2003), Naslund presents a fictional work set amidst the period when four African American school girls were killed in the racially motivated bombing of Sixteenth Street Baptist Church in Birmingham during the civil rights era. The novel was also selected as a Notable Book by the New York Times, Los Angeles Times, Seattle Times, and Louisville Courier-Journal. Her novel Abundance: A Novel of Marie Antoinette (also a national best seller in 2006) employs fiction to shed new light on the vilified queen of France during the French Revolution. In 2010's Adam & Eve, she explores creation myths, biblical folklore, and human agency, and in The Fountain of St. James Court; or, Portrait of the Artist as an Old Woman (2013), centers on women as creative agents through a novel within a novel about an eighteenth-century woman painter.
In 2005, Kentucky governor Ernie Fletcher named Naslund Poet Laureate of Kentucky. At the University of Louisville, she has been awarded the University Distinguished Teaching Professor Award and the President's Award for Outstanding Creative Activity. The Alabama Writers Forum and Alabama Writers Symposium awarded Naslund the Harper Lee Award for Alabama's Distinguished Writer in 2001. Naslund also received the Alabama Author Award from the Alabama Library Association in 2001 and the Southeastern Library Association Fiction Award in 2003-2004. She has received grants from the National Endowment for the Arts, the Kentucky Arts Council, and the Kentucky Foundation for Women.

Naslund lives in Louisville and is . Naslund is currently a Distinguished Teaching Professor and Writer in Residence at the University of Louisville, as well as the director of Spalding University's brief-residency Master of Fine Arts Program in Creative Writing. She continues as editor of The Louisville Review and of the Fleur-de-Lis Press.
Works by Sena Jeter Naslund
Ice Skating at the North Pole: Stories (1989)
Works by Sena Jeter Naslund
Ice Skating at the North Pole: Stories (1989)
Sherlock In Love: A Novel (1993)
The Animal Way to Love: A Novel (1993)
Ahab's Wife: or, The Star-Gazer: A Novel (1999)
The Disobedience of Water: Stories and Novellas (1999)
Four Spirits: A Novel (2003)
Abundance: A Novel of Marie Antoinette (2006)
Adam & Eve (2010)